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Updated: Oct 20, 2025
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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
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Pituitary surgery for Cushing's disease.
Bertrand Baussart1, Stephan Gaillard2
1Department of Neurosurgery, La Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, 7013, Paris, France. bertrand.baussart@aphp.fr.
Acta Neurochirurgica
|September 14, 2021
Summary
This study details a specialized endoscopic surgery for Cushing's disease, emphasizing a planned strategy for successful outcomes. This approach is crucial for achieving high remission rates in patients with this complex condition.
Area of Science:
- Neurosurgery
- Endocrinology
- Pituitary Disorders
Background:
- Cushing's disease surgery demands technical expertise, particularly when preoperative imaging lacks clear adenoma identification.
- Endoscopic endonasal surgery is the primary treatment for Cushing's disease.
Purpose of the Study:
- To report the specific techniques and challenges of mononostril endoscopic endonasal surgery for Cushing's disease.
- To highlight a surgical strategy for improved patient outcomes.
Main Methods:
- Analysis of 683 Cushing's disease patients operated on between 2006 and 2020.
- Utilized a mononostril endoscopic endonasal approach performed by two senior neurosurgeons.
Main Results:
- A rigorous and planned surgical strategy was employed.
- This approach aims to overcome surgical difficulties in Cushing's disease.
Conclusions:
- A well-defined surgical strategy is key to avoiding complications in Cushing's disease surgery.
- The described approach leads to a high rate of endocrine remission.
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