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Updated: Oct 20, 2025
10:12
Visualization of G3BP Stress Granules Dynamics in Live Primary Cells
Published on: May 21, 2014
18.5K
Research Progress on the Structure and Function of G3BP.
Weifang Kang1, Yue Wang1, Wenping Yang1
1State Key Laboratory of Veterinary Etiological Biology and OIE/National Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Frontiers in Immunology
|September 16, 2021
Summary
Ras-GTPase-activating protein (G3BP) is an RNA-binding protein crucial for stress granule formation and has dual roles in antiviral defense and viral replication. Its dysregulation is linked to various diseases.
Area of Science:
- Molecular Biology
- Virology
- Cell Biology
Background:
- Ras-GTPase-activating protein (SH3 domain)-binding protein (G3BP) is a key RNA-binding protein involved in stress granule (SG) formation.
- G3BP interacts with numerous host proteins, regulating SG expression and cellular responses.
- G3BP plays a significant role in both innate antiviral immunity and viral pathogenesis.
Purpose of the Study:
- To review the significant discoveries and developments concerning G3BP over the past two decades.
- To elucidate the multifaceted roles of G3BP in SG assembly, viral interactions, RNA stability, and disease progression.
Main Methods:
- Literature review of scientific publications.
- Analysis of G3BP's interactions with host and viral proteins.
- Examination of G3BP's role in RNA regulation and disease pathogenesis.
Main Results:
- G3BP acts as an antiviral factor by interacting with viral proteins to modulate SG assembly.
- Conversely, viruses can hijack G3BP to promote their own replication by recruiting translation factors.
- G3BP's regulation of mRNA translation and attenuation connects it to diseases like cancer and neurodevelopmental disorders.
Conclusions:
- G3BP is a pivotal protein with complex roles in cellular stress responses, viral dynamics, and human health.
- Understanding G3BP's functions is critical for developing therapeutic strategies against viral infections and related diseases.
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