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Updated: Oct 20, 2025
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
COVID-19 and Fulminant Clostridium difficile Colitis Co-Infection
Abdul Ahad Ehsan Sheikh1, Abu Baker Sheikh2, Ishan Shah2
1The Wright Center for Graduate Medical Education, Department of Internal Medicine, Scranton, PA, USA.
Abstract:
The development of Clostridium difficile infection in COVID-19 patients is an understudied complication of the disease. Herein, we present the case of a 46-year-old man who developed severe healthcare-associated C. difficile infection leading to toxic megacolon and perforation in the setting of COVID-19 infection. It is important to continue to follow guidelines regarding antibiotics in healthcare settings to prevent such complications.
Learning Points:
Co-infection with Clostridium difficile and COVID-19 leads to poor outcomes with high mortality.C. difficile infection should be ruled out in COVID-19 patients who develop diarrhoea on antibiotic therapy.We should continue to follow the established guidelines of antimicrobial stewardship and remain vigilant for unexpected adverse effects.
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