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Corneal biomechanical properties in hyperthyroidism and thyroid eye disease
M Reza Razeghinejad1,2, Amir R Farsiani1,3, Ramin Salout1,4
1Poostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Summary
Corneal biomechanical properties differ in individuals with hyperthyroidism, both with and without thyroid eye disease, compared to euthyroid individuals. These findings are crucial for managing conditions like glaucoma and planning refractive surgeries.
Area of Science:
- Ophthalmology
- Endocrinology
- Corneal Biomechanics
Background:
- Thyroid dysfunction, including hyperthyroidism, can affect ocular health.
- Thyroid eye disease (TED) is a known complication of thyroid dysfunction.
- Corneal biomechanical properties are crucial for ocular health and surgical outcomes.
Purpose of the Study:
- To compare corneal biomechanical properties in hyperthyroid individuals without ophthalmopathy (HWO), those with thyroid eye disease (TED), and euthyroid controls.
- To investigate potential differences in corneal structure and function related to thyroid status.
Main Methods:
- Prospective comparative study involving HWO, TED, and euthyroid participants.
- Corneal biomechanical properties measured using ocular response analyzer and Corvis ST tonometers.
- Participants evaluated for thyroid function and orbitopathy by specialists.
Main Results:
- Hyperthyroid groups (HWO and TED) showed altered corneal biomechanical parameters compared to euthyroid controls.
- Specific differences included changes in corneal hysteresis (CH) and highest concavity deformation amplitude (HCDA).
- Ocular findings like exophthalmos correlated with specific biomechanical measures.
Conclusions:
- Corneal biomechanical properties are significantly altered in individuals with hyperthyroidism, irrespective of ophthalmopathy.
- These alterations may have implications for managing ocular conditions such as glaucoma.
- Understanding these changes is important for optimizing outcomes in refractive surgeries.
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