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Aberrant functional brain network dynamics in patients with functional constipation.

Tao Yin1,2, Zhaoxuan He1,2,3, Peihong Ma1,2

  • 1Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Human Brain Mapping
|September 17, 2021
PubMed
Summary
This summary is machine-generated.

Functional constipation (FCon) patients exhibit altered brain connectivity dynamics, particularly involving the default mode and cognitive control networks. These changes in brain network states correlate with symptom severity, offering new therapeutic targets.

Keywords:
anterior insulabrain dynamicsfunctional connectivityfunctional constipationgraph theory

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Systems Biology

Background:

  • Static functional connectivity alterations are known in functional constipation (FCon).
  • The dynamic functional connectivity and network organization in FCon remain largely unexplored.
  • Understanding brain dynamics is crucial for FCon pathophysiology.

Purpose of the Study:

  • To investigate dynamic functional connectivity states in FCon patients.
  • To analyze network topological organization changes over time in FCon.
  • To correlate aberrant brain dynamics with FCon symptom severity.

Main Methods:

  • Spatial group independent component analysis and sliding-window approach.
  • K-means clustering to identify recurring functional connectivity states.
  • Graph-theoretic analysis to assess network topology and nodal efficiency.

Main Results:

  • Four distinct functional connectivity states were identified.
  • FCon patients showed reduced occurrence and dwell time in a state linking default mode and cognitive control networks.
  • Aberrant anterior insula-cortical coupling and increased nodal efficiency entropy in FCon were linked to symptom severity.

Conclusions:

  • FCon is associated with altered dynamic brain network states and topology.
  • Specific connectivity patterns involving the anterior insula are critical and symptom-related.
  • These findings provide a dynamic connectomic perspective for FCon treatment development.