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Heart failure in COVID-19: the multicentre, multinational PCHF-COVICAV registry

Mateusz Sokolski1,2, Sander Trenson2,3, Justyna M Sokolska1,2

  • 1Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.

ESC Heart Failure
|September 17, 2021
PubMed

Insights

Hospitalized patients with COVID-19 and heart failure (HF) faced higher in-hospital mortality. Acute HF events during hospitalization further increased death risk, underscoring HF

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Heart failure (HF) is a significant comorbidity impacting outcomes in hospitalized patients.
  • Coronavirus disease 2019 (COVID-19) has been associated with cardiovascular complications.
  • The interplay between HF and COVID-19 requires further investigation to understand mortality risks.

Purpose of the Study:

  • To compare the outcomes of hospitalized COVID-19 patients with HF against those with other cardiovascular diseases or risk factors.
  • To determine the incidence of HF events during COVID-19 hospitalization.
  • To assess the consequences of HF events on mortality in COVID-19 patients.

Main Methods:

  • Retrospective analysis of the Postgraduate Course in Heart Failure registry (PCHF-COVICAV) data.
  • Inclusion of patients hospitalized with COVID-19 and cardiovascular disease/risk factors from 28 centers in 15 countries.
  • Primary endpoint: in-hospital mortality; secondary analysis of acute HF events and their impact.

Main Results:

  • Of 1282 COVID-19 patients with cardiovascular disease/risk factors, 256 (20%) had HF. Overall in-hospital mortality was 25%.
  • Patients with HF had significantly higher in-hospital mortality (36%) compared to non-HF patients (23%, OR 1.93, P < 0.001).
  • 15% of patients experienced acute HF events during hospitalization (de novo HF in 40%), associated with substantially higher mortality (48% vs. 23%, OR 3.10, P < 0.001).

Conclusions:

  • Hospitalized COVID-19 patients with a history of HF face a significantly increased risk of in-hospital death.
  • Acute heart failure events, including new-onset HF, are common during COVID-19 hospitalization.
  • These HF events are associated with a further, substantial rise in in-hospital mortality, highlighting the critical impact of HF management in this population.
Abstract

Keywords:
COVID-19Cardiovascular diseaseHeart failureRisk factorsSARS-CoV2

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