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Temporal changes and prognostic value of plasma ghrelin level in patients with acute heart failure: a prospective

Yanbo Chen1,2, Sani Zhou3, Aiyuan Zhang2

  • 1Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Heart and Vessels
|September 17, 2021
PubMed

Insights

Elevated plasma ghrelin levels in acute heart failure (AHF) patients are linked to adverse outcomes. Higher ghrelin at 3 hours independently predicts major adverse cardiac events (MACEs) in AHF patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biomarkers

Background:

  • Plasma ghrelin levels are often elevated in patients diagnosed with acute heart failure (AHF).
  • Understanding the dynamic changes and predictive capability of ghrelin in AHF is crucial for patient management.

Purpose of the Study:

  • To investigate the temporal patterns of plasma ghrelin levels in patients with AHF.
  • To determine the prognostic significance of ghrelin levels for predicting major adverse cardiac events (MACEs) in AHF.

Main Methods:

  • A prospective study involving AHF patients and healthy controls.
  • Measurement of plasma ghrelin levels at multiple time points.
  • Utilized multivariable logistic regression and ROC curve analysis to assess MACE prediction.

Main Results:

  • AHF patients exhibited higher ghrelin levels compared to controls at 1, 3, 12, and 24 hours.
  • Ghrelin levels peaked at 3 and 12 hours in AHF patients.
  • Elevated ghrelin levels at 1 and 3 hours were associated with MACEs; 3-hour ghrelin was an independent predictor of MACEs.

Conclusions:

  • Plasma ghrelin levels are significantly elevated in AHF patients.
  • Ghrelin levels in AHF correlate with cardiac function indicators and predict future MACEs.
Abstract

Keywords:
Acute heart failureBNPEjection fractionGhrelinPrognosis

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