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Gastroenterology Clinical Trials Transparency: An Analysis of Publication Rates From the ClinicalTrials.gov Database

Shashank Garg1, Anam Rizvi2, Diana Wee3

  • 1Division of Gastroenteorlogy, Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

The American Journal of Gastroenterology
|September 17, 2021
PubMed
Abstract

Insights

Most gastroenterology clinical trials report results, but few post them on ClinicalTrials.gov. Improving clinical trial transparency in gastroenterology is essential for research integrity.

Area of Science:

  • Gastroenterology
  • Clinical Trials
  • Research Transparency

Background:

  • Limited information exists regarding the transparency of clinical trials in gastroenterology.
  • Ensuring transparency in clinical research is crucial for public trust and scientific advancement.

Purpose of the Study:

  • To assess the transparency of clinical trials for common gastrointestinal diseases.
  • To evaluate the adherence to reporting results for gastroenterology trials.

Main Methods:

  • A systematic search of the ClinicalTrials.gov database was conducted for trials related to prevalent gastrointestinal diseases up to August 2018.
  • Data on trial characteristics and results reporting (via ClinicalTrials.gov or publication) were collected for each trial.

Main Results:

  • Out of 2,429 analyzed trials, 75% had results available either on ClinicalTrials.gov or in publications.
  • However, only 29% of these trials had their results posted directly on the ClinicalTrials.gov database.

Conclusions:

  • A significant gap exists in the reporting of clinical trial results on ClinicalTrials.gov within the field of gastroenterology.
  • Enhancing clinical trial transparency in gastroenterology is necessary to ensure comprehensive data accessibility and research accountability.

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