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Related Concept Videos

Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
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Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Glaucoma following Infant Lensectomy: 2021 Update.

David S Walton1, Helen H Yeung1

  • 1Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States.

Klinische Monatsblatter Fur Augenheilkunde
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Summary
This summary is machine-generated.

Infantile aphakic glaucoma may result from anterior chamber fibrosis after lensectomy surgery. This fibrosis, linked to lens cell dispersion, can damage the filtration angle and impair function.

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Area of Science:

  • Ophthalmology
  • Pediatric Surgery
  • Glaucoma Research

Background:

  • Infant lensectomy surgery is performed for congenital cataracts.
  • Glaucoma is a potential sight-threatening complication following this procedure.

Purpose of the Study:

  • To review existing literature on glaucoma after infant lensectomy.
  • To elucidate the underlying mechanisms of this condition.

Main Methods:

  • Assessment of risk factors and proposed mechanisms for infantile aphakic glaucoma.
  • Analysis of clinical evidence in affected patients.
  • Review of postoperative anterior chamber fibrosis.

Main Results:

  • Identified risk factors and proposed mechanisms for infantile aphakic glaucoma.
  • Analyzed clinical presentations of glaucoma post-lensectomy.
  • Interpreted evidence of anterior chamber fibrosis.

Conclusions:

  • Postoperative anterior chamber fibrosis is a key factor in infantile aphakic glaucoma.
  • Lens cell dispersion and epithelial-mesenchymal transition contribute to fibrosis.
  • Fibrosis leads to filtration angle injury and functional loss, causing glaucoma.