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Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

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Changes in serum magnesium concentration after strenuous exercise.

G Stendig-Lindberg, Y Shapiro, Y Epstein

Journal of the American College of Nutrition

|February 1, 1987

Summary

Strenuous hiking significantly lowers serum magnesium (S-Mg) levels, indicating a potential magnesium deficiency. This effect persists for at least three months post-exertion, even after initial recovery.

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Area of Science:

Exercise Physiology
Nutritional Biochemistry
Sports Medicine

Background:

Serum magnesium concentration (S-Mg) plays a crucial role in various physiological processes.
Strenuous physical activity is known to influence electrolyte balance.
Previous studies suggest a decrease in S-Mg following intense exercise.

Purpose of the Study:

To investigate the longitudinal changes in serum magnesium concentration after a 120 km hike in highly trained young men.
To determine if strenuous exertion leads to a persistent magnesium deficiency.

Main Methods:

Serum magnesium (S-Mg) levels were measured in 20 young men before, and at 1, 24, 72 hours, and 3 months after a 120 km hike.
Serum creatine kinase (CK) activity was assessed to evaluate muscle damage.
Statistical analysis (Student's t-test) was employed to determine significant changes in S-Mg.

Main Results:

S-Mg significantly decreased immediately after the 120 km hike.
A transient increase in S-Mg was observed at 24 hours, coinciding with elevated CK levels, suggesting muscle membrane disruption.
S-Mg remained significantly lower than baseline at 72 hours and persisted at a reduced level 3 months post-hike.

Conclusions:

A 120 km hike induces a biphasic alteration in serum magnesium, with a significant and prolonged decrease.
The persistent lowering of S-Mg suggests that strenuous exertion can lead to a magnesium deficiency.
Further research is warranted to understand the long-term implications of exercise-induced magnesium deficiency.