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Molecular dynamics simulation of TMEM16A channel: Linking structure with gating

Sai Shi1, Chunli Pang2, Shuxi Ren2

  • 1State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300401, China; Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province, Hebei University of Technology, Tianjin 300401, China; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Science, Hebei University of Technology, Tianjin 300401, China.

Biochimica Et Biophysica Acta. Biomembranes
|September 19, 2021
PubMed
Summary

Calcium-activated chloride channel TMEM16A gating mechanisms were revealed through molecular dynamics. Calcium binding repositions key residues, altering the pore structure and facilitating ion passage.

Keywords:
ANO1CaCCsElectrostatic potentialGatingIon channelTMEM16A

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