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Updated: Oct 19, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Colocating Wound Care for Patients with Sickle Cell Ulcers in a Hematology Clinic
Anna Flattau1, Giacomo Vinces, Shuo You
1At the Albert Einstein College of Medicine and Montefiore Health System, Bronx, New York, Anna Flattau, MD, MS, MSc, is Associate Professor and Vice Chair, Department of Family and Social Medicine; Giacomo Vinces, DO, is Assistant Professor, Department of Family and Social Medicine; Shuo You, MD, is Research Coordinator, Division of Hematology, Department of Medicine; Andrew S. Crouch, BA, is Research Coordinator, Division of Hematology, Department of Medicine; and Caterina P. Minniti, MD, is Professor, Division of Hematology, Department of Medicine. Acknowledgment: This work was partially supported by a grant from the FDA (R01FD005729). The authors have disclosed no other financial relationships related to this article. Submitted October 29, 2020; accepted in revised form November 23, 2020.
Objective:
Leg ulcers affect 15% of people with sickle cell disease. However, wound centers typically treat few people with this condition, which makes it difficult to concentrate clinical expertise or support the scientific study of this orphan disease. This article describes an initiative to increase engagement in care through a partnership between wound healing and hematology leadership that led to colocating wound services within a sickle cell clinic.
Methods:
Via a retrospective chart review, the authors collected records of all adult patients with sickle cell disease who received wound care in the last decade, including 7 years of wound center data and 3 years of data from the colocated services. Patient and visit characteristics were analyzed using descriptive analytics.
Results:
The general wound center had previously treated 35 patients with sickle cell ulcers over 7 years. In contrast, colocated services engaged 56 patients within 3 years, including 20 who transferred care and 36 new patients. The majority of patients at the colocated site were women, unlike at the wound center (58% vs 47%, P = .07). Results indicated that 36% of patients healed initial wounds, and 45% had new wound occurrences.
Conclusions:
Colocation successfully increases the number of patients with sickle cell ulcers who will engage in wound care at a single site, laying the foundation for clinical studies to improve the evidence base for this difficult-to-treat condition.
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