Related Experiment Video
Updated: Oct 19, 2025

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
Acute Respiratory Distress Syndrome: Ventilator Management and Rescue Therapies
Melissa H Coleman1, J Matthew Aldrich2
1Division of Cardiothoracic Surgery, Department of Surgery, Critical Care Medicine, University of California, San Francisco, 500 Parnassus Avenue, MUW-405, Box 0118, San Francisco, CA 94143, USA.
Abstract:
This review describes the management of mechanical ventilation in patients with acute respiratory distress syndrome, including in those with coronavirus disease 2019. Low tidal volume ventilation with a moderate to high positive end-expiratory pressure remains the foundation of an evidence-based approach. We consider strategies for setting positive end-expiratory pressure levels, the use of recruitment maneuvers, and the potential role of driving pressure. Rescue therapies including prone positioning and extracorporeal membrane oxygenation are also discussed.
Related Concept Videos
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Cardiopulmonary Resuscitation II: ACLS Airway Management
Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques
Acute Respiratory Failure-III
Mechanical Ventilation I: Indication and Settings
Ventilatory Modes
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...

