[MHT: Who benefits? Who does not benefit?]

Area of Science:

• Reproductive endocrinology
• Preventive medicine
• Endocrinology

Background:

• Menopausal Hormone Therapy (MHT) is a common treatment for menopausal symptoms.
• Understanding the specific benefits and contraindications of MHT is crucial for personalized patient care.

Purpose of the Study:

• To identify patient groups who benefit from individually adapted MHT.
• To determine patient groups who do not benefit from MHT.
• To explore the preventive health effects of MHT, including its impact on type II diabetes mellitus.

Main Methods:

• Review of existing literature on MHT efficacy and safety.
• Analysis of patient data considering known contraindications.
• Evaluation of MHT's impact on the incidence of type II diabetes mellitus.

Main Results:

• Individually adapted MHT, when prescribed considering contraindications, demonstrates direct preventive health effects.
• MHT use is associated with a reduction in the incidence of type II diabetes mellitus, indicating secondary preventive benefits.

Conclusions:

• Personalized MHT regimens offer significant preventive health advantages.
• MHT may play a role in the secondary prevention of type II diabetes mellitus.