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Updated: Oct 19, 2025

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
Published on: May 18, 2022
Longevity leap: mind the healthspan gap
Armin Garmany1,2,3, Satsuki Yamada1,2,4, Andre Terzic5,6,7,8
1Center for Regenerative Medicine, Marriott Family Comprehensive Cardiac Regenerative Medicine, Marriott Heart Disease Research Program, Van Cleve Cardiac Regenerative Medicine Program, Mayo Clinic, Rochester, MN, USA.
While life expectancy has increased, healthspan has not kept pace due to chronic diseases. Prioritizing disease-free longevity through integrated interventions and advanced technologies is crucial for global wellbeing.
Area of Science:
- Gerontology and Public Health
- Epidemiology of Aging
- Biomedical Interventions
Background:
- Significant increase in life expectancy over the past century.
- Discrepancy between increased lifespan and healthspan.
- Growing burden of chronic diseases in aging populations.
Purpose of the Study:
- To outline contemporary trends in extending healthspan.
- To address the challenge of age-related multimorbidity and frailty.
- To propose a multidimensional approach to bridge the healthspan-lifespan gap.
Main Methods:
- Review of communal, clinical, and research trends.
- Analysis of evolving epidemiological data.
- Integration of public health initiatives with emerging biotechnologies.
Main Results:
- Identification of key challenges in achieving parallel healthspan expansion.
- Outline of strategies integrating societal efforts and clinical interventions.
- Highlighting the potential of anti-senescent and regenerative medicine.
Conclusions:
- A coordinated, multidimensional approach is necessary to improve quality of life in older adults.
- Investment in anti-senescent and regenerative technologies is vital.
- Cost-effective validation is required for equitable global healthspan extension.
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