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Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
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Parapharyngeal Lymph Node Metastasis From Papillary Thyroid Carcinoma.

Mohamed Masmoudi1, Mehdi Hasnaoui1, Manel Njima2

  • 1Department of Otolaryngology-Head and Neck Surgery, Tahar Sfar Hospital, Mahdia, Tunisia.

Ear, Nose, & Throat Journal
|September 24, 2021
PubMed
Summary

Metastatic parapharyngeal lymph nodes (LNs) from papillary thyroid carcinoma (PTC) are rare but can be detected by elevated serum thyroglobulin (TG) levels. This case highlights diagnosis, treatment, and prognosis of these uncommon PTC metastases.

Keywords:
lymph nodemetastasispapillary carcinomaparapharyngeal spacethyroid

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Area of Science:

  • Oncology
  • Head and Neck Surgery
  • Endocrinology

Background:

  • Metastatic parapharyngeal lymph nodes (LNs) from papillary thyroid carcinoma (PTC) are infrequently encountered and often overlooked.
  • Elevated serum thyroglobulin (TG) levels can indicate recurrence or metastasis in patients with a history of PTC.

Observation:

  • A 62-year-old woman with a history of PTC presented with elevated serum thyroglobulin (TG) levels.
  • Computed tomography (CT) revealed metastatic nodes in the left parapharyngeal space (PPS).

Findings:

  • Surgical resection of the parapharyngeal metastatic lymph nodes was successfully performed via an external cervical approach.
  • Histological examination confirmed the metastatic nature of the lymph nodes originating from the PTC.

Implications:

  • This case underscores the importance of considering PPS as a potential site for PTC metastasis, even when rare.
  • Diagnostic modalities like CT scans and monitoring of serum TG levels are vital for identifying these metastases.
  • Prompt diagnosis and surgical intervention can impact the overall prognosis for patients with advanced PTC.