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Updated: Oct 19, 2025
Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
Published on: December 30, 2016
Spurious phase correction in rapid metabolic imaging
Nour El Sabbagh1, Carine Chassain1, Hélène Ratiney2
1INRAE, UR QuaPA, F-63122 Saint-Gènes-Champanelle, France; INRAE, AgroResonance Facility, F-63122 Saint-Genès-Champanelle, France; Université Clermont Auvergne, CHU, CNRS, Clermont Auvergne INP, Institut Pascal, F-63000 Clermont-Ferrand, France.
Magnetic Resonance Spectroscopic Imaging (MRSI) requires precise phase control for accurate metabolite mapping. This study details how transmit/receive frequency switching causes spurious phase errors and presents correction methods for IDEAL-type MRSI sequences.
Area of Science:
- Magnetic Resonance Imaging
- Spectroscopy
- Medical Physics
Background:
- IDEAL-type Magnetic Resonance Spectroscopic Imaging (MRSI) sequences are crucial for metabolite mapping.
- These sequences necessitate acquiring multiple datasets with optimized time-domain sampling.
- Accurate phase variation during evolution time is critical, depending solely on chemical shifts.
Purpose of the Study:
- To describe the occurrence of spurious phase artifacts in IDEAL-type MRSI.
- To investigate the impact of transmit and receive frequency switching on phase errors.
- To present necessary corrections for these phase artifacts based on commutation methods.
Main Methods:
- Utilized IDEAL spiral method on a preclinical MRI scanner.
- Employed a 13C phantom for experimental illustration.
- Analyzed phase variations arising from transmit/receive frequency commutation.
Main Results:
- Identified spurious phase artifacts originating from transmit or receive frequency switching.
- Demonstrated that phase error depends on the location and mode (continuous/coherent) of frequency commutation.
- Presented case-specific and universal correction strategies for phase artifacts.
Conclusions:
- Understanding frequency commutation is vital for correcting phase errors in IDEAL MRSI.
- Some correction methods are universally applicable, while others depend on scanner implementation.
- Experimental validation was performed using a 13C phantom on a preclinical MRI system.
