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Bioactive Agent-Loaded Electrospun Nanofiber Membranes for Accelerating Healing Process: A Review.
Seyyed-Mojtaba Mousavi1, Zohre Mousavi Nejad2, Seyyed Alireza Hashemi3
1Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan.
Membranes
|September 26, 2021
Summary
Bioactive electrospun dressings mimic natural skin extracellular matrix (ECM) for enhanced wound healing. This review explores recent advancements in these dressings, focusing on incorporating bioactive agents for improved therapeutic potential in treating acute and chronic wounds.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Care
Background:
- Current wound dressings fail to replicate healthy skin properties, posing challenges in wound healing.
- Electrospinning technology offers a promising approach by creating nanofiber structures similar to the natural extracellular matrix (ECM).
- This similarity enhances the potential for effective wound management and skin regeneration.
Purpose of the Study:
- To provide an overview of recent developments in bioactive electrospun wound dressings.
- To discuss the incorporation of bioactive agents to improve therapeutic efficacy.
- To compare commercial bioactive dressings and suggest future research directions.
Main Methods:
- Review of recent literature on electrospun wound dressings and bioactive agents.
- Analysis of strategies for incorporating bioactive agents into nanofiber membranes.
- Comparison of features and capabilities of commercial bioactive dressings.
Main Results:
- Electrospun dressings demonstrate significant potential in accelerating wound healing due to their ECM-like nanostructures.
- Incorporation of various bioactive agents enhances the therapeutic capabilities of these dressings for acute and chronic wounds.
- Commercial dressings show diverse features and capabilities, highlighting ongoing innovation in the field.
Conclusions:
- Bioactive electrospun dressings represent a significant advancement in wound healing and skin regeneration.
- Further research into bioactive agent-loaded nanofiber membranes is crucial for developing next-generation wound care solutions.
- Optimizing these dressings can lead to more effective treatments for challenging wounds.
