Related Experiment Video
Updated: Oct 19, 2025
Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Spectrum of Multisystem Inflammatory Syndrome in Children (MIS-C)-a Report of Three Cases
Shruti Jain1, Archana Kashyap1, Amitabh Singh1
1Department of Pediatrics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, 110029 India.
Insights
Multisystem inflammatory syndrome in children (MIS-C) can present differently and critically in pediatric patients. Early recognition and prompt management are crucial for improving outcomes in children with MIS-C.
Area of Science:
- Pediatrics
- Infectious Diseases
- Critical Care Medicine
Background:
- Multisystem inflammatory syndrome in children (MIS-C) is a serious condition linked to COVID-19.
- Understanding MIS-C's diverse clinical presentations is vital for timely diagnosis and treatment.
Observation:
- Three critically ill pediatric patients (ages 1-12) with MIS-C presented with fever, conjunctivitis, GI symptoms, and skin rash.
- Clinical signs included shock, coagulopathy, and multiorgan dysfunction.
- Elevated inflammatory markers (CRP, ESR, D-dimers) were noted in all cases.
Findings:
- All patients required intensive care, including oxygen, fluid resuscitation, inotropes, and antibiotics.
- Treatment involved steroids, with two patients receiving intravenous immunoglobulin.
- Outcomes varied, with one fatality and two discharges.
Implications:
- COVID-19 can lead to severe MIS-C in children with varied presentations.
- Early identification and prompt, aggressive management are essential for pediatric MIS-C cases.
- This case series highlights the need for heightened clinical suspicion and preparedness in managing pediatric inflammatory syndromes.
Abstract:
We report three cases of multisystem inflammatory syndrome in children (MIS-C) during July 2020 from a tertiary care hospital with different clinical presentations and course of management. This will guide in better management of children with MIS-C. All three patients, aged 1 to 12 years old, were critically ill. They presented with common features of MIS-C, such as fever, conjunctival congestion, gastrointestinal involvement, and skin manifestations. Clinical features were suggestive of shock, coagulopathy, and multiorgan involvement. Laboratory findings revealed raised inflammatory markers, including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and D-dimers (DD). All patients required intensive care with oxygen therapy, fluid resuscitation, inotropic agents, and broad-spectrum antibiotics. All patients received steroids, and two patients were given intravenous immunoglobulin. One patient died, and the remaining two patients were discharged. Our findings confirmed that COVID-19 may cause severe disease in children, and the presentation may vary, requiring early recognition and timely management.
Related Concept Videos
01:27Myocarditis II: Clinical Features and Diagnostic Tests
01:19Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
01:14Myocarditis III: Medical Management