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Updated: Oct 18, 2025

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
Published on: September 15, 2018
MicroRNAs in Hypertrophic, Arrhythmogenic and Dilated Cardiomyopathy
Enrica Chiti1, Marco Di Paolo2, Emanuela Turillazzi2
1Institute of Life Science, Scuola Superiore Sant'Anna, 56124 Pisa, Italy.
Abstract:
MicroRNAs (miRNAs) are a class of non-coding RNAs of about 20 nucleotides in length, involved in the regulation of many biochemical pathways in the human body. The level of miRNAs in tissues and circulation can be deregulated because of altered pathophysiological mechanisms; thus, they can be employed as biomarkers for different pathological conditions, such as cardiac diseases. This review summarizes published findings of these molecular biomarkers in the three most common structural cardiomyopathies: human dilated, arrhythmogenic and hypertrophic cardiomyopathy.
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