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Multifocal Visual Evoked Potentials (mfVEP) for the Detection of Visual Field Defects in Glaucoma: Systematic Review
Haitao Liu1, Fei Liao1, Román Blanco2,3
1Physiology Unit, Department of Systems Biology, School of Medicine, University of Alcalá, 28005 Madrid, Spain.
Journal of Clinical Medicine
|September 28, 2021
Summary
Multifocal visual evoked potential (mfVEP) amplitude demonstrates high diagnostic precision for detecting visual field defects in glaucoma patients. This analysis confirms mfVEP amplitude as a reliable indicator for glaucoma visual field studies.
Area of Science:
- Ophthalmology
- Neuroscience
Background:
- Discrepancies exist in multifocal visual evoked potential (mfVEP) diagnostic efficacy for glaucoma visual field defects.
- Accurate diagnostic indicators are crucial for effective glaucoma management.
Purpose of the Study:
- To evaluate the diagnostic precision of mfVEP in glaucoma patients.
- To identify the best diagnostic indicator of mfVEP for visual field defects.
Main Methods:
- Systematic review and meta-analysis of quantitative studies up to April 2021.
- Inclusion of six studies with 241 glaucoma patients.
- Calculation of sensitivity, specificity, diagnostic odds ratio, and AUC using ROC curve analysis.
Main Results:
- The overall AUC was 0.98, indicating high diagnostic accuracy.
- Pooled sensitivity and specificity for mfVEP amplitude were 0.93 and 0.89, respectively.
- Positive and negative likelihood ratios were 6.56 and 0.08, respectively, with no publication bias.
Conclusions:
- mfVEP amplitude exhibits strong diagnostic precision in predicting visual field defects in glaucoma.
- Interocular mfVEP amplitude analysis is a valuable diagnostic tool for visual field assessment in glaucoma.
