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Exocrine Pancreatic Function in Girls with Anorexia Nervosa
Żaneta Malczyk1, Wojciech Roczniak2, Bogdan Mazur3
1Chair and Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. 3 Maja 13/15, 41-800 Zabrze, Poland.
Nutrients
|September 28, 2021
Summary
Pancreatic lipase secretion efficiency is normal in anorexia nervosa, but its release kinetics are altered, potentially due to disrupted adipose-insular and islet-acinar axes.
Area of Science:
- Endocrinology
- Gastroenterology
- Nutritional Science
Background:
- Anorexia nervosa (AN) is associated with various physiological disturbances.
- Pancreatic exocrine function has not been fully elucidated in AN.
Purpose of the Study:
- To evaluate pancreatic exocrine function in AN patients using a 13C-labeled mixed triglycerides breath test (MTG-BT).
- To investigate the correlation between MTG-BT results and biochemical/hormonal parameters.
Main Methods:
- 31 girls with restrictive AN and 38 healthy controls (C) underwent anthropometric measurements, biochemical/hormonal assays (leptin, sLR, ghrelin, FLI), and MTG-BT.
- Breath test measured 13C-triglyceride recovery (%CD) and time to peak 13CO2 excretion (TTP).
Main Results:
- %CD was similar between AN and C groups.
- TTP was significantly longer in AN patients compared to controls.
- %CD negatively correlated with free leptin index (FLI) in both groups.
- TTP showed negative correlations with soluble leptin receptor (sLR) and FLI in AN, and with insulin and HOMA-IR in controls.
Conclusions:
- Pancreatic lipase secretion efficiency is normal in girls with AN.
- The kinetics of lipase secretion are disturbed in AN.
- These kinetic changes may stem from dysregulation of the adipose-insular and islet-acinar axes.
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