Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:19

Cell Migration

5.4K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
5.4K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

3.3K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
3.3K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.8K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.8K
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

2.1K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
2.1K
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

3.0K
The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
3.0K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

5.0K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The mechanical microenvironment and lung stem cell fate.

Frontiers in cell and developmental biology·2026
Same author

Patterns of mitochondrial ATP predict tissue folding.

Science advances·2026
Same author

TGFβ determines epithelial tissue spacing by regulating mesenchymal condensation.

bioRxiv : the preprint server for biology·2026
Same author

Fat promotes growth and invasion in a 3D microfluidic tumor model of triple-negative breast cancer.

APL bioengineering·2026
Same author

Mapping embryonic mouse lung development using enhanced spatial transcriptomics.

bioRxiv : the preprint server for biology·2025
Same author

Fuel, form, and memory: The motility-driven journey of cancer cells.

Current opinion in biomedical engineering·2025
Same journal

Increased rates of hybridization in swordtails are associated with water pollution.

Current biology : CB·2026
Same journal

Visual uncertainty and task demands shape active sensing strategies in mice.

Current biology : CB·2026
Same journal

An adaptable, self-organizing, single-cell morphology circuit optimizes suctorian predatory trap structure.

Current biology : CB·2026
Same journal

Temporal tuning of switch-like virulence expression resolves environmental uncertainty through phenotypic heterogeneity.

Current biology : CB·2026
Same journal

An abstract relational map emerges in the human medial prefrontal cortex with consolidation.

Current biology : CB·2026
Same journal

Phloem evolved gradually and asynchronously to xylem in early vascular plants.

Current biology : CB·2026
See all related articles

Related Experiment Video

Updated: Oct 18, 2025

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix
08:49

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Published on: July 10, 2016

7.7K

Dynamic changes in epithelial cell packing during tissue morphogenesis.

Sandra B Lemke1, Celeste M Nelson2

  • 1Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.

Current Biology : CB
|September 28, 2021
PubMed
Summary
This summary is machine-generated.

Organ shape arises from cell packing. This review explores common cellular mechanisms driving tissue morphogenesis, including cell shape changes, rearrangements, and division, for engineering 3D tissues.

More Related Videos

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

9.7K
Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo
08:19

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

13.1K

Related Experiment Videos

Last Updated: Oct 18, 2025

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix
08:49

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Published on: July 10, 2016

7.7K
Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

9.7K
Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo
08:19

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

13.1K

Area of Science:

  • Developmental biology
  • Cell biology
  • Tissue engineering

Background:

  • Cell packing, the spatial arrangement of cells, is fundamental to organ shape determination.
  • Epithelial tissues employ dynamic cellular mechanisms to alter cell packing and generate functional architectures during development.

Purpose of the Study:

  • To review cellular mechanisms of cell packing and tissue morphogenesis across diverse developmental processes.
  • To identify common motifs in the morphogenesis toolbox for tissue shape changes.
  • To highlight approaches for engineering three-dimensional tissues.

Main Methods:

  • Review of cellular mechanisms in epithelial tissues across various model organisms.
  • Analysis of developmental processes including tissue elongation, folding, invagination, and branching.
  • Identification of key cellular behaviors: cell-shape changes, cell rearrangements, and oriented cell division.

Main Results:

  • Common cellular motifs underlying tissue morphogenesis have been identified.
  • These motifs, through combinations, enable diverse changes in tissue shape.
  • Specific cellular processes like cell-shape changes, rearrangements, and oriented divisions are key drivers.

Conclusions:

  • Epithelial cell packing dynamics provide a framework for understanding tissue shaping.
  • Identified morphogenetic mechanisms offer insights into developmental processes.
  • Understanding these dynamics facilitates advancements in tissue engineering for basic and translational research.