Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Metabolism01:19

Regulation of Metabolism

10.4K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
10.4K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

25
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
25
Aging01:26

Aging

329
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
329
What is Metabolism?00:52

What is Metabolism?

122.1K
Overview
122.1K
Overview of Metabolism01:40

Overview of Metabolism

35.3K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
35.3K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

43
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
43

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesia.

bioRxiv : the preprint server for biology·2026
Same author

Mechanistic corticostriatal circuit model predicts learning-dependent fMRI dynamics and individual reward bias in humans.

bioRxiv : the preprint server for biology·2026
Same author

Brain age prediction in generalized anxiety disorder using a convolutional neural network.

Translational psychiatry·2026
Same author

Generation of Pathway Signatures by Combining Normal Modes with Weighted Ensemble Simulations.

bioRxiv : the preprint server for biology·2026
Same author

Curvature on Graphs with Negative Edge Weights.

IEEE transactions on network science and engineering·2026
Same author

A principled basis for nonequilibrium network flows.

Nature communications·2026

Related Experiment Video

Updated: Oct 18, 2025

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
08:36

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

447

Metabolism modulates network synchrony in the aging brain.

Corey Weistuch1,2, Lilianne R Mujica-Parodi1,3,4,5,6, Rostam M Razban1

  • 1Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794.

Proceedings of the National Academy of Sciences of the United States of America
|September 30, 2021
PubMed
Summary

Brain aging reduces network synchrony due to decreased metabolism. Older brains near a critical point exhibit abrupt network changes, suggesting metabolism drives brain reorganization.

Keywords:
agingcriticalityfMRIneurometabolismsynchrony

More Related Videos

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.4K
A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.3K

Related Experiment Videos

Last Updated: Oct 18, 2025

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
08:36

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

447
Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.4K
A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.3K

Area of Science:

  • Neuroscience
  • Statistical Physics
  • Gerontology

Background:

  • Brain aging is linked to reduced metabolism and altered functional connectivity.
  • Network synchrony, a measure of collective brain activity, declines with age.

Purpose of the Study:

  • To investigate the relationship between brain metabolism, network synchrony, and aging.
  • To model age-related changes in brain network topology.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) to measure brain activity.
  • Quantitative methods from statistical physics, including a generative Ising model.
  • Experimental modulation of metabolic activity in younger adults.

Main Results:

  • Network synchrony decreases with age.
  • Older brains are closer to a critical point related to communication strength.
  • Metabolic changes alone can induce significant reorganization of brain network topology.

Conclusions:

  • Reduced metabolism is a key factor in age-related decline of brain network synchrony.
  • Brain aging may involve proximity to a critical state, amplifying metabolic effects.
  • Metabolic modulation offers a potential mechanism for age-related brain network changes.