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Progressive Pleural Effusion as an Immune-Related Adverse Event in NSCLC: A Case Report

Chia-I Shen1,2,3, Yi-Chen Yeh3,4, Chao-Hua Chiu1,3

  • 1Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

JTO Clinical and Research Reports
|September 30, 2021
PubMed

Immune checkpoint inhibitors (ICIs) have improved the clinical outcome of NSCLC. However, immune-related adverse events (irAEs) such as pneumonitis, thyroiditis, and colitis have been reported with the increasing use of ICIs. The diagnosis of irAEs relies on exclusion. With proper management, most patients may still benefit from ICI treatment. Pleural effusion is a rare presentation of an irAE. Here, we report a patient who experienced progressive bilateral pleural effusions during the first-line treatment of cisplatin, pemetrexed, and pembrolizumab. Serial study and surgical pleural biopsy found the possible cause of irAE. His pleural effusion subsided after discontinuing therapy. IrAE may present as pleural effusion and physicians should be alert to unknown causes of pleural effusion in patients under ICI treatment.

Keywords:
Case reportImmune-related adverse eventImmunotherapyNon–small cell lung cancerPleural effusion

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