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Updated: Oct 18, 2025

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
Overview of Innervation of Knee Joint
John Tran1, Philip W H Peng2, Vincent W S Chan2
1Division of Anatomy, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, 1 King's College Circle, Room 1158, Toronto, Ontario M5S 1A8, Canada.
Abstract:
Image-guided diagnostic block and radiofrequency ablation of the knee joint to manage pain require detailed understanding of joint innervation in relation to soft tissue and bony landmarks. In this article, the origin, course, and relationship to anatomic landmarks of articular nerves supplying the knee joint are discussed. The innervation pattern of the anterior and posterior aspects of the knee joint capsule is relatively consistent, with some variation in supply by the saphenous, anterior division of obturator, and common fibular nerves. To improve nerve capture rates for diagnostic block and radiofrequency ablation, multiple target sites could be beneficial.
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