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Decrease in Serum Urate Level Is Associated With Loss of Visceral Fat in Male Gout Patients.
Zijing Ran1, Xiaomei Xue1, Lin Han1,2,3
1Shandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, The Affiliated Hospital of Qingdao University, Qingdao, China.
Frontiers in Endocrinology
|October 1, 2021
Summary
Urate-lowering therapy significantly reduces serum urate levels and visceral fat in gout patients. Lowering serum urate is linked to visceral fat reduction, suggesting a potential therapeutic benefit of ULT for metabolic health.
Area of Science:
- Metabolic Syndrome
- Rheumatology
- Cardiovascular Health
Background:
- Gout is a metabolic condition characterized by hyperuricemia.
- Visceral fat accumulation is linked to metabolic syndrome and cardiovascular disease.
- The relationship between serum urate levels and visceral fat in gout patients requires further clarification.
Purpose of the Study:
- To investigate the association between serum urate (SU) decrease and visceral fat area (VFA) reduction in male patients with gout.
- To determine if urate-lowering therapy (ULT) impacts visceral fat levels.
Main Methods:
- Retrospective analysis of 237 male gout patients undergoing urate-lowering therapy (ULT).
- Measurements of body composition and metabolic parameters were taken within a 6-month period.
- Multiple linear regression was used to evaluate the relationship between changes in SU (ΔSU) and changes in VFA (ΔVFA).
Main Results:
- ULT led to a significant decrease in mean SU levels (from 464.22 to 360.93 μmol/L, p < 0.001).
- A significant reduction in median VFA was observed (from 97.30 to 90.90, p < 0.001).
- ΔSU was a significant determinant of VFA decrease (beta = 0.302, p = 0.001).
Conclusions:
- A decrease in serum urate levels is positively associated with a reduction in visceral fat.
- These findings suggest that ULT may promote visceral fat loss in gout patients.
- Further clinical trials are warranted to confirm the effect of ULT on visceral fat reduction.
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