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Updated: Oct 18, 2025

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
Published on: September 9, 2015
Dalbavancin.
J Barberán1, A de la Cuerda, L C Barberán
1José Barberán, Servicio de Medicina Interna - Enfermedades Infecciosas, Hospital Universitario HM Montepríncipe Universidad San Pablo CEU, Madrid, Spain. jbarberan@ceu.es.
Dalbavancin is a potent antimicrobial effective against Gram-positive bacteria and biofilms. Its long half-life enables convenient weekly dosing for skin infections and other therapeutic uses.
Area of Science:
- Pharmacology
- Microbiology
- Infectious Diseases
Background:
- Dalbavancin exhibits potent in vitro activity against Gram-positive pathogens.
- Staphylococcal biofilms are a significant challenge in treating persistent infections.
Purpose of the Study:
- To evaluate the efficacy and safety of dalbavancin.
- To highlight its potential use beyond current indications.
Main Methods:
- In vitro antimicrobial activity assessment.
- Review of clinical data for off-label use.
Main Results:
- Dalbavancin demonstrates excellent activity against Gram-positive bacteria and biofilms.
- A long terminal half-life (149-250 hours) supports weekly dosing.
- Successful and safe use in real-world clinical practice for various infections, including consolidation therapy.
Conclusions:
- Dalbavancin is a valuable long-acting antimicrobial for Gram-positive infections.
- Its pharmacokinetic profile supports extended dosing intervals.
- Clinical experience suggests broader utility beyond acute bacterial skin and skin structure infections.
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