Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hebbian synapses in hippocampus.

S R Kelso, A H Ganong, T H Brown

    Proceedings of the National Academy of Sciences of the United States of America
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Weekend admission and mortality for gastrointestinal disorders across England and Wales.

    The British journal of surgery·2017
    Same author

    Tuberculous pancreatitis complicated by ruptured splenic artery pseudoaneurysm.

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace·2014
    Same author

    Gastrointestinal bleeding in a pregnant woman: mucinous cystic neoplasm of pancreas mimicking gastrointestinal stromal tumor of stomach.

    Journal of hepato-biliary-pancreatic surgery·2009
    Same author

    Seat belt injury causing delayed sigmoid colon fistula.

    Emergency medicine journal : EMJ·2009
    Same author

    Fear conditioning to discontinuous auditory cues requires perirhinal cortical function.

    Behavioral neuroscience·2008
    Same author

    Auditory trace fear conditioning requires perirhinal cortex.

    Neurobiology of learning and memory·2008
    Same journal

    Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Tomographic imaging of superconducting order using particle-hole interference.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Analytical modeling for suction cup designs for skin-interfaced wearable devices.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Improving cell-free metabolism through direct integration of artificial respiratory chains.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    See all related articles

    Repetitive postsynaptic spiking drives associative synaptic enhancement, but involves unknown biophysical processes. This mechanism explains the cooperativity of long-term potentiation in hippocampal synapses.

    Area of Science:

    • Neuroscience
    • Synaptic Plasticity
    • Computational Neuroscience

    Background:

    • Hebbian learning postulates that synaptic enhancement requires concurrent pre- and postsynaptic activity.
    • Associative long-term potentiation (LTP) in hippocampal synapses exhibits properties like cooperativity, suggesting specific induction mechanisms.
    • The precise biophysical events underlying Hebbian-like synaptic plasticity remain incompletely understood.

    Purpose of the Study:

    • To investigate the role of postsynaptic electrogenesis in associative synaptic enhancement.
    • To elucidate the specific biophysical mechanisms controlling Hebbian-like plasticity.
    • To determine if these mechanisms can account for the properties of LTP, including cooperativity.

    Main Methods:

    • Utilized current- and voltage-clamp techniques on hippocampal brain slices.

    Related Experiment Videos

  • Applied repetitive postsynaptic stimulation to induce synaptic changes.
  • Examined the spatiotemporal specificity of synaptic enhancement in relation to presynaptic activity.

    • Main Results:

    • Repetitive postsynaptic spiking induced synaptic enhancement only when presynaptic activity was concurrent.
    • Identified novel biophysical processes in postsynaptic electrogenesis as critical for this enhancement.
    • Demonstrated that this pseudo-Hebbian mechanism exhibits spatiotemporal specificity.

    Conclusions:

    • Postsynaptic electrogenesis, involving previously unknown biophysical events, is crucial for associative synaptic enhancement.
    • This mechanism provides a qualitative explanation for the neurophysiological properties of associative long-term potentiation.
    • The findings help explain the cooperativity requirement for long-term potentiation in hippocampal synapses.