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Pulpal response to mineral trioxide aggregate containing phosphorylated pullulan-based capping material.

Yu Toida1, Shimpei Kawano1,2, Rafiqul Islam1

  • 1Department of Restorative Dentistry, Faculty of Dental Medicine, Hokkaido University.

Dental Materials Journal
|October 4, 2021
PubMed
Summary

A new mineral trioxide aggregate material (MTAPPL) shows promise for direct pulp capping (DPC). Studies indicate MTAPPL promotes healing and mineralized tissue formation with minimal inflammation, suggesting it

Keywords:
Calcium hydroxideDirect pulp cappingMineral trioxide aggregatePhosphorylated pullulan

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Area of Science:

  • Biomaterials Science
  • Dental Pulp Biology
  • Regenerative Dentistry

Background:

  • Direct pulp capping (DPC) aims to preserve pulp vitality.
  • Novel biomaterials are needed to improve DPC outcomes.
  • Mineral trioxide aggregate (MTA) derivatives are investigated for enhanced biocompatibility.

Purpose of the Study:

  • To evaluate the pulpal responses following direct pulp capping (DPC) using a novel phosphorylated pullulan-based mineral trioxide aggregate (MTAPPL).
  • To compare the efficacy of MTAPPL against established DPC materials: Nex-Cem MTA (NX), TheraCal LC (TH), and Dycal (DY).

Main Methods:

  • Seventy-two monkey teeth underwent DPC with MTAPPL, NX, TH, or DY.
  • Histopathological analysis of pulpal tissues was performed at 3, 7, and 70 days post-procedure.
  • Evaluation focused on inflammatory responses and mineralized tissue formation (MTF).

Main Results:

  • At day 3, MTAPPL showed mild inflammation, while NX and DY exhibited moderate responses.
  • Initial mineralized tissue formation was observed by day 7 in MTAPPL, NX, and TH groups.
  • By day 70, MTAPPL, NX, and TH demonstrated no inflammation and complete MTF with odontoblast-like cells.

Conclusions:

  • MTAPPL exhibits excellent biocompatibility and regenerative potential for direct pulp capping.
  • The novel MTAPPL material is comparable to established agents like TheraCal LC and Nex-Cem MTA.
  • MTAPPL represents a potentially efficient and effective option for clinical direct pulp capping procedures.