Related Experiment Video
Updated: Oct 18, 2025

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
Amyloidosis: A Rare Cause of Severe Cholestasis and Acute Liver Failure
Hyun Jae Kim1, Marcel Tomaszewski2, Eric C Lam2
1Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Abstract:
Although hepatic involvement in light chain-associated amyloidosis is common, clinical manifestations of hepatic amyloidosis are rare. In most cases, hepatomegaly serves as a clue to diagnosis. We report a unique case of a 48-year-old man from China with jaundice and noncirrhotic portal hypertension, with rapidly progressive liver failure, in the absence of hepatomegaly, secondary to systemic light chain-associated amyloidosis associated with multiple myeloma.
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