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X-ray Imaging01:24

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German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
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The non-destructive nature and ability to provide valuable chemical information make IR spectroscopy a versatile technique with broad applications in various scientific and industrial fields. IR spectroscopy is commonly used to identify and characterize organic and inorganic compounds. It provides information about the functional groups present in a molecule and the bonding between atoms. This helps in the structural elucidation of compounds during organic synthesis, pharmaceutical research,...
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The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
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Organic Compound with Potential for X-ray Imaging Applications.

Gopika V Gopan1, K Kezia Susan1, Enakshy Rajan Jayadevan2

  • 1Division of Polymeric Medical Devices, Department of Medical Devices Engineering, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojappura, Trivandrum 695012, Kerala, India.

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A novel tetraiodinated diphenolic acid derivative was synthesized, showing high radiopacity (64% iodine content) and non-cytotoxicity. This compound shows potential for use in X-ray imaging applications.

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Area of Science:

  • Materials Science
  • Radiology
  • Organic Chemistry

Background:

  • Development of effective radiopaque agents is crucial for medical imaging.
  • Existing agents may have limitations in radiopacity or biocompatibility.

Purpose of the Study:

  • To synthesize and characterize a novel, highly radiopaque compound.
  • To evaluate the potential of this compound for X-ray imaging applications.

Main Methods:

  • Synthesis via electrophilic aromatic iodination of diphenolic acid.
  • Characterization using FTIR, NMR, EDX, Mass Spectrometry, UV-Vis, and thermogravimetry.
  • Radiopacity assessment using computed tomography (CT) and cytotoxicity evaluation via MTT assay.

Main Results:

  • A tetraiodo compound with 64% iodine content by weight was successfully synthesized.
  • The compound exhibited significant radiopacity (885 ± 7 Hounsfield Units at 5% concentration).
  • In vitro cytotoxicity tests showed the compound was non-cytotoxic to L929 fibroblast cells up to 0.8 mg/mL.

Conclusions:

  • The synthesized tetraiodinated compound demonstrates high radiopacity and good biocompatibility.
  • This novel compound holds promise as a potential agent for clinical X-ray imaging.