Related Experiment Video

Updated: Oct 17, 2025

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
07:52

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

12.2K

Ischemic Preconditioning of the Kidney

E Yu Plotnikov1,2

  • 1A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University, Moscow, Russia. plotnikov@belozersky.msu.ru.

Bulletin of Experimental Biology and Medicine
|October 7, 2021
PubMed

Insights

Ischemic preconditioning protects kidneys from injury by brief oxygen deprivation cycles. Understanding its molecular pathways could lead to new therapies for acute kidney injury and chronic kidney disease.

Area of Science:

  • Nephrology
  • Cardiovascular Physiology
  • Molecular Biology

Background:

  • Ischemic preconditioning (IP) is a protective phenomenon observed in various organs, including the kidneys, involving brief cycles of ischemia/reperfusion.
  • Acute kidney injury (AKI) affects millions globally, leading to significant mortality, while chronic kidney disease (CKD) impacts nearly 10% of the adult population.
  • Kidney IP is considered a highly effective strategy for preventing AKI, highlighting the need to understand its underlying molecular mechanisms for therapeutic development.

Purpose of the Study:

  • To review the key signaling pathways involved in kidney ischemic preconditioning.
  • To explore potential pharmacological agents that mimic key elements of kidney IP.
  • To discuss limitations of IP-based therapies, particularly age-related decreases in renal ischemic tolerance.

Main Methods:

  • Literature review of studies on kidney ischemic preconditioning.
  • Analysis of molecular signaling pathways implicated in renal IP.
  • Evaluation of pharmacological approaches and age-related effects on kidney IP.

Main Results:

  • Identified key signaling pathways crucial for kidney ischemic preconditioning.
  • Discussed pharmacological mimetics that could replicate IP's protective effects.
  • Highlighted age-related decline in renal ischemic tolerance as a significant limitation.

Conclusions:

  • Understanding kidney IP molecular mechanisms is vital for developing nephroprotective therapies.
  • Pharmacological mimetics offer potential for enhancing renal tolerance to oxygen deficiency.
  • Age-dependent alterations in IP necessitate further research for effective clinical translation.
Keywords:
acute renal injuryhypoxiaischemiaischemic tolerancemitochondria

More Related Videos

Use of a Hanging-weight System for Isolated Renal Artery Occlusion07:54

Use of a Hanging-weight System for Isolated Renal Artery Occlusion

Published on: July 19, 2011

16.2K
Murine Kidney Transplant Technique08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

16.5K

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
86
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
239
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
162
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
82
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
71
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
273