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Related Concept Videos

Signs of Puberty01:27

Signs of Puberty

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Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Nature and Nurture01:10

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Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
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Sex-linked Disorders01:43

Sex-linked Disorders

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Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Incomplete Dominance01:43

Incomplete Dominance

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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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Updated: Oct 17, 2025

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
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Genetics of pubertal delay.

Tansit Saengkaew1,2, Sasha R Howard1

  • 1Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Clinical Endocrinology
|October 7, 2021
PubMed
Summary
This summary is machine-generated.

Genetic factors significantly impact pubertal timing. Advances in genetic sequencing have improved understanding and diagnosis of delayed puberty disorders over the last 20 years.

Keywords:
delayed pubertyhypogonadotropic hypogonadismpuberty

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Area of Science:

  • Reproductive endocrinology
  • Human genetics
  • Developmental biology

Background:

  • Pubertal timing is influenced by genetics, with familial inheritance patterns common in delayed puberty.
  • Recent advances in next-generation sequencing have shed light on the genetic underpinnings of pubertal timing disorders.

Purpose of the Study:

  • To review significant advancements in understanding the biological mechanisms of delayed puberty.
  • To highlight the role of genetic discoveries in diagnosing pubertal timing disorders.

Main Methods:

  • Literature review of research published in the last two decades.
  • Analysis of studies focusing on genetic regulators of pubertal development.
  • Synthesis of findings on the pathogenesis of delayed puberty.

Main Results:

  • Identification of key genetic regulators influencing the timing of puberty.
  • Demonstration of clear inheritance patterns for delayed puberty within families.
  • Advancement in understanding the biological pathways involved in pubertal timing.

Conclusions:

  • Genetic testing is increasingly valuable for diagnosing delayed puberty.
  • Understanding genetic mechanisms has significantly improved the diagnosis and management of pubertal disorders.
  • The last two decades have seen substantial progress in unraveling the genetic basis of delayed puberty.