Construction of Carbon-Fluorine Bonds via Copper-Catalyzed/-Mediated Fluorination Reactions
1Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
Abstract:
The construction of carbon-fluorine bonds is an important yet challenging task in organic synthesis. Transition metal-catalyzed/-mediated C-F bond forming processes have recently emerged as a viable strategy and provided access to value-added monofluorinated compounds. A dramatic increase in fluorination methods using inexpensive and earth-abundant copper can be seen in the past decade surpassing those using palladium and silver. This review discusses the recent development of Cu-catalyzed/-mediated formation of C(sp2 )-F and C(sp3 )-F bonds.
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