Related Experiment Video

Updated: Oct 17, 2025

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

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68Ga-FAPI and 18F-PET/CT Images in Intestinal Tuberculosis

Jieling Zheng1, Kaixian Lin1, Shan Zheng1

  • 1From the Department of Nuclear Medicine.

Clinical Nuclear Medicine
|October 7, 2021
PubMed

Insights

This study explores the use of 68Ga-FAPI PET/CT for diagnosing intestinal tuberculosis. Results suggest 68Ga-FAPI PET/CT may be valuable in evaluating this condition, showing more extensive peritoneal involvement than 18F-FDG PET/CT.

Area of Science:

  • Nuclear medicine
  • Gastroenterology
  • Infectious diseases

Background:

  • Intestinal tuberculosis presents diagnostic challenges.
  • 18F-FDG PET/CT can show inflammation but may lack specificity.
  • Fibroblast Activation Protein Inhibitor (FAPI) PET/CT is an emerging imaging modality.

Observation:

  • A patient with abdominal pain and weight loss showed intestinal and peritoneal lesions on 18F-FDG PET/CT.
  • 68Ga-FAPI PET/CT revealed intense uptake in these lesions and more extensive peritoneal abnormalities.
  • Biopsy confirmed intestinal tuberculosis.

Findings:

  • 68Ga-FAPI PET/CT demonstrated higher sensitivity for peritoneal involvement in intestinal tuberculosis compared to 18F-FDG PET/CT.
  • FAPI uptake correlated with FDG-avid lesions, suggesting FAPI targets active disease processes.
  • The imaging findings were consistent with the final diagnosis of tuberculosis.

Implications:

  • 68Ga-FAPI PET/CT shows promise as a valuable tool for evaluating intestinal tuberculosis.
  • This imaging technique may improve the detection and assessment of peritoneal disease in tuberculosis.
  • Further research is warranted to establish the role of 68Ga-FAPI in diagnosing and managing intestinal tuberculosis.

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