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Rare neonatal malignant primary orbital tumors: Three case reports
Yan Zhang1, Yue-Yue Li2, Han-Yang Yu1
1Department of Ophthalmology, The Seventh Medical Center of PLA General Hospital, Beijing 100700, China.
World Journal of Clinical Cases
|October 8, 2021
Summary
Malignant orbital tumors are rare in newborns. Unilateral proptosis in neonates may indicate aggressive tumors, requiring prompt diagnosis and management.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Pathology
Background:
- Aggressive malignant primary orbital tumors are exceptionally rare in neonates.
- This study clarifies clinical features of these rare tumors in newborns.
Observation:
- Three neonates presented with unilateral proptosis at birth.
- Histopathologic examination revealed diverse diagnoses: peripheral primary neuroectodermal tumor, aggressive infantile fibromatosis, and embryonic rhabdomyosarcoma.
- One infant died due to widespread metastasis despite chemotherapy.
Findings:
- Surgical excision alone was successful for two infants, with complete healing and normal development at 6 months and 1 year follow-up.
- The varied diagnoses highlight the diverse nature of orbital tumors in neonates.
- Early detection and appropriate treatment are crucial for favorable outcomes.
Implications:
- Unilateral proptosis in newborns warrants consideration of malignant primary orbital tumors.
- Timely surgical intervention may lead to favorable outcomes in select cases.
- Further research into the management of rare neonatal orbital malignancies is needed.
