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Related Concept Videos

Adhesion01:14

Adhesion

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Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
42.1K

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Bioengineered Protein-based Adhesives for Biomedical Applications.

Jing Sun1,2, Jiaying Han2, Fan Wang3

  • 1Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|October 8, 2021
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Summary
This summary is machine-generated.

Genetic engineering enhances protein-based adhesives for superior underwater adhesion and biocompatibility. This review details advances in bioengineered adhesives from elastin-like polypeptides, mussel foot proteins, and spider silk for biomedical uses.

Keywords:
biomedical applicationelastin-like polypeptidegenetically engineeringmussel foot proteinprotein adhesive

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Area of Science:

  • Biomaterials Science
  • Biotechnology
  • Adhesion Science

Background:

  • Protein-based adhesives offer strong adhesion and biocompatibility.
  • Mussel and sandcastle worm proteins inspire synthetic adhesive development.
  • Current synthetic adhesives lack robust underwater performance and biocompatibility.

Purpose of the Study:

  • To review recent advances in bioengineered protein-based adhesives.
  • To summarize fabrication, adhesion performance, and biomedical applications.
  • To provide future perspectives on bioengineered adhesives.

Main Methods:

  • Genetic engineering of protein-based adhesives.
  • Fabrication and characterization of elastin-like polypeptide (ELP) based adhesives.
  • Review of mussel foot protein (mfp), spider silk spidroin, and suckerin based adhesives.

Main Results:

  • Bioengineered adhesives maintain underwater adhesion and biocompatibility.
  • ELP, mfp, spider silk, and suckerin based adhesives show promising adhesion.
  • Diverse biomedical applications are being explored for these materials.

Conclusions:

  • Genetic engineering is key to overcoming limitations of synthetic adhesives.
  • Bioengineered protein adhesives show significant potential for biomedical applications.
  • Future research should focus on optimizing these materials for clinical translation.