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Updated: Oct 17, 2025
Author Spotlight: Enhancing Coronary Artery Revascularization
Published on: September 15, 2023
Comparison of Microplegia Solution and Del Nido Cardioplegia Solution in Coronary Artery Bypass Grafting Surgery:
Yusuf Salim Urcun1, Arda Aybars Pala2
1Department of Cardiovascular Surgery, Adiyaman Training and Research Hospital, Adiyaman, Turkey. ys_urcun@hotmail.com.
Insights
Del Nido cardioplegia offers superior myocardial protection compared to microplegia during coronary artery bypass surgery. This solution also reduces cross-clamp times, enhancing surgical efficiency and patient outcomes.
Area of Science:
- Cardiovascular Surgery
- Cardioplegia Solutions
- Myocardial Protection
Background:
- Coronary artery bypass surgery (CABG) requires effective myocardial protection.
- Comparing microplegia and Del Nido cardioplegia is crucial for optimizing surgical outcomes.
Purpose of the Study:
- To compare the efficacy of microplegia and Del Nido cardioplegia in CABG.
- To evaluate clinical, biochemical, and echocardiographic outcomes between the two cardioplegia solutions.
Main Methods:
- A comparative study of 300 patients undergoing CABG.
- Data collected included cardiac biomarkers, cross-clamp and CPB times, and echocardiographic measurements.
- Patients were operated on by the same surgical team between January 2017 and January 2020.
Main Results:
- Del Nido cardioplegia group had significantly shorter cross-clamp times (55.60 ± 13.49 min vs. 75.58 ± 12.43 min).
- Better preservation of left and right ventricular ejection fraction was observed in the Del Nido group.
- Lower requirement for inotropic support was noted in the Del Nido group (28% vs. 44%).
Conclusions:
- Del Nido cardioplegia demonstrates superior short-term myocardial protection compared to microplegia.
- Single-dose administration of Del Nido cardioplegia allows for longer cross-clamp times (up to 90 min), improving surgical comfort.
- Del Nido cardioplegia is a preferred option for enhanced myocardial protection and reduced cross-clamp times in CABG.
Background:
The aim of this study is to compare the efficacy of the microplegia solution and Del Nido cardioplegia solution in coronary artery bypass surgery with clinical, biochemical, and echocardiographic data.
Methods:
Three hundred patients, who underwent coronary artery bypass surgery between January 2017 and January 2020, by the same surgical team were included in the study. Preoperative, operative and postoperative data (cardiac biomarker levels, cross-clamp and CPB times, echocardiographic measurements, etc.) of the patients were compared.
Results:
In the study, cross-clamp time was significantly shorter in the DN cardioplegia group (55.60 ± 13.49 min/75.58 ± 12.43 min, P = 0.024). No significant difference was observed between the two groups in terms of intensive care stay, extubation time, hospital stay, and cardiopulmonary bypass time. In our study, it was shown that both the left and right ventricular ejection fraction was better protected in the Del Nido cardioplegia group (5.34±3.03 vs. 3.40±2.84, P = 0.017 and 3.82±1.19 vs. 2.28±1.87, P = 0.047, respectively), and the need for inotrope support was lower in this group (28% vs. 44%, P < 0.021). There was no significant difference between the groups, in terms of blood transfusion rates, IABP requirement.
Conclusion:
In light of short-term results, we can say that Del Nido cardioplegia provides better myocardial protection than microplegia. In addition, Del Nido cardioplegia can be given as a single dose for 90 minutes of cross-clamp time and therefore can be preferred to increase surgical comfort and reduce cross-clamp times.
