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Published on: March 1, 2024
Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma
Haixiao Fang1, Riri Shi1, Ding Chen1
1Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, P. R. China. iamcwzhang@njtech.edu.cn.
Abstract:
MAO-A promotes the proliferation of human glioma cells. Herein, we report a series of MAO-A specific two-photon small molecular fluorescent probes (A1-5) based on an intramolecular charge transfer enhancing strategy. The activity of endogenous MAO-A can be selectively imaged using A3 as a representative probe in different biological samples including human glioma cells/tissues via two-photon fluorescence microscopy. The study provides new tools for the visual detection of glioma.
