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Updated: Oct 16, 2025
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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
Published on: November 9, 2020
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Proteasome Based Molecular Strategies Against Improper Cellular Proliferation.
Ankur Rakesh Dubey1, Sumit Kinger1, Yuvraj Anandrao Jagtap1
1Cellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan, India.
Summary
The ubiquitin proteasome system (UPS) maintains cell health and proteostasis. Dysfunctional UPS contributes to cancer, and targeting UPS offers new therapeutic strategies for cancer treatment.
Area of Science:
- Molecular Biology
- Cellular Biology
- Biochemistry
Background:
- Cellular proteins perform multiple functions essential for survival.
- Proteostasis, regulated by the ubiquitin proteasome system (UPS), is crucial for preventing diseases like cancer and neurodegeneration.
- Cancer cells exhibit enhanced cytoprotective properties, often linked to dysregulated UPS components.
Purpose of the Study:
- To review cellular protein quality control mechanisms and the role of UPS in cancer.
- To discuss UPS involvement in cancer pathomechanisms and therapeutic strategies.
- To summarize recent advances in proteasome-associated pathways for cancer treatment.
Main Methods:
- Literature review of cellular protein quality control.
- Analysis of UPS functions in cancer pathomechanisms.
- Review of therapeutic strategies targeting UPS in cancer.
Main Results:
- UPS is a primary proteostasis mechanism vital for cytoprotection.
- Dysregulation of UPS components is implicated in various stages of tumor progression.
- Targeting UPS can influence cancer cell apoptosis and tumor progression.
Conclusions:
- Understanding UPS and protein quality control is key to developing novel cancer therapies.
- UPS plays a critical role in regulating cancer cell survival and apoptosis.
- Targeting proteasomal pathways offers promising therapeutic interventions for complex diseases.
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