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Related Concept Videos

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Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Related Experiment Video

Updated: Oct 16, 2025

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Cutaneous Multiple Myeloma.

Leela Krishna Vamsee Miriyala1, Deepti Avasthi1

  • 1Internal Medicine, St. Vincent Mercy Medical Center, Toledo, USA.

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|October 18, 2021
PubMed
Summary
This summary is machine-generated.

Multiple myeloma, a plasma cell cancer, rarely spreads to the skin. This case report details a unique instance of primary cutaneous multiple myeloma with rare associated conditions.

Keywords:
amyloidosis and multiple myelomachemotherapy-inducedcutaneous malignant melanomacutaneous multiple myelomaextramedullary multiple myelomalenalidomidesecondary primary cancersquamous cell carcinoma (scc)

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Area of Science:

  • Hematology
  • Oncology
  • Dermatology

Background:

  • Multiple myeloma is a plasma cell dyscrasia with characteristic CRAB criteria (hypercalcemia, renal insufficiency, anemia, bone lesions).
  • Cutaneous manifestations of multiple myeloma are uncommon, with metastasis being exceedingly rare.

Observation:

  • This report presents a rare case of biopsy-confirmed primary cutaneous multiple myeloma.
  • The patient exhibited unusual features including renal amyloidosis and a concurrent malignant melanoma.

Findings:

  • Primary cutaneous multiple myeloma is an exceptionally rare presentation of the disease.
  • The co-occurrence of renal amyloidosis and malignant melanoma adds complexity to this unique case.

Implications:

  • This case highlights the diverse and rare presentations of multiple myeloma.
  • Understanding such unique cases can improve diagnostic accuracy and patient management for rare myeloma phenotypes.