Proximity labeling: an enzymatic tool for spatial biology
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Updated: Oct 16, 2025
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Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics
Published on: June 23, 2022
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Chang-Ryul Choi1, Hyun-Woo Rhee2
1Department of Chemistry, Seoul National University, Seoul 08826, Korea.
Trends in Biotechnology
|October 19, 2021
Abstract:
In this Forum, we highlight how cutting-edge, proximity-dependent, enzymatic labeling tools, aided by sequencing technology developments, have enabled the extraction of spatial information of proteomes, transcriptomes, genome organization, and cellular networks. We also discuss the potential applications of proximity labeling in the unexplored field of spatial biology in live systems.
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