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A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
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[Hepatitis C virus cell entry]
1Inserm U758, Lyon ; École normale supérieure de Lyon ; IFR128 BioSciences Lyon-Gerland, Lyon.
Virologie (Montrouge, France)
|October 23, 2021
Summary
Hepatitis C virus (HCV) cell entry mechanisms are becoming clearer thanks to emerging in vitro models. This review details the roles of HCV envelope glycoproteins E1 and E2 in viral attachment, receptor interactions, and fusion.
Area of Science:
- Virology
- Molecular Biology
Context:
- Hepatitis C virus (HCV), a significant human pathogen, is an enveloped, positive-stranded RNA virus.
- Understanding HCV cell entry is crucial due to its global health impact.
Purpose:
- To review the contribution of various HCV model systems to understanding viral cell entry.
- To summarize knowledge on the structure and function of HCV envelope glycoproteins E1 and E2 in cell entry.
Summary:
- HCV cell entry involves initial attachment via low-affinity molecules and subsequent high-affinity receptor interactions.
- The process includes endocytosis, trafficking, and fusion mediated by viral glycoproteins.
- Emerging in vitro systems are now aiding the study of HCV replication and particle formation.
Impact:
- Advances knowledge of Hepatitis C virus pathogenesis.
- Provides insights into viral entry mechanisms for potential therapeutic targets.
