Related Experiment Video
Updated: May 1, 2026
12:48
PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
Published on: December 27, 2013
67.2K
PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application
Se Min Kim1, Madhumita Patel2, Rajkumar Patel3
1Life Science and Biotechnology Department (LSBT), Underwood Division (UD), Underwood International College, Yonsei University, Sinchon, Seoul 03722, Korea.
Polymers
|October 23, 2021
Summary
Poly (lactic-co-glycolic acid) (PLGA) core-shell nanoparticles offer advanced drug delivery for cancer therapy and tissue regeneration. These particles protect drugs and enable controlled release, showing significant biomedical potential.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Core-shell particles possess unique structures enabling diverse biomedical applications at nano/micro scales.
- Poly (lactic-co-glycolic acid) (PLGA), an FDA-approved polymer, is a recognized material for drug delivery vehicles.
- These particles are crucial for sequence-controlled drug release and offer drug protection.
Purpose of the Study:
- To review poly (lactic-co-glycolic acid) (PLGA) core-shell nano/microparticles.
- To summarize drug delivery systems utilizing these particles for cancer therapy.
- To explore applications in tissue regeneration, including bone, cartilage, and periodontal regeneration.
Main Methods:
- Literature review of PLGA core-shell nano/microparticle applications.
- Analysis of drug delivery mechanisms for cancer treatment.
- Evaluation of regenerative medicine strategies using PLGA particles.
Main Results:
- PLGA core-shell particles demonstrate significant potential in controlled drug delivery.
- These systems are effective for targeted cancer therapy.
- Promising outcomes observed in bone, cartilage, and periodontal tissue regeneration.
Conclusions:
- PLGA core-shell nano/microparticles are versatile platforms for advanced biomedical applications.
- Their unique structure facilitates effective drug delivery for cancer and regeneration.
- Further research into PLGA-based systems will advance therapeutic strategies.
Keywords:
anti-cancer activitycore–shell particledrug deliveryperiodontal regenerationtissue engineeringMore Related Videos
Related Concept Videos
01:16Drug Delivery: Overview
466
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
466
01:18Drug Delivery: Enteral Route
859
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
859
01:29Drug Delivery: Parenteral Route
977
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
977
01:22Drug Delivery: Miscellaneous Routes
532
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
532
01:27Bioavailability Enhancement: Drug Permeability Enhancement
16
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
16
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
15
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
15