Cellulosic/Polyvinyl Alcohol Composite Hydrogel: Synthesis, Characterization and Applications in Tissue Engineering
Mathilde Stricher1, Claude-Olivier Sarde2, Erwann Guénin2
1Université de Technologie de Compiègne, CNRS, Biomechanics and Bioengineering, Centre de Recherche Royallieu, CEDEX CS 60 319, 60 203 Compiègne, France.
Polymers
|October 23, 2021
Summary
We developed a novel cellulose-based hydrogel for tissue engineering. The DAC 9%/PVA material shows excellent cytocompatibility and physical stability for soft tissue graft applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Polymer Chemistry
Background:
- The biomedical field needs advanced composite materials for medical devices and tissue engineering scaffolds.
- There is a demand for non-animal and non-proteic scaffold alternatives.
Purpose of the Study:
- To synthesize and characterize cellulose-based hydrogels for tissue engineering applications.
- To evaluate the cytocompatibility and in vivo stability of these novel hydrogels.
Main Methods:
- Dialdehyde-functionalized microcrystalline cellulose (DAC) synthesized via sodium periodate oxidation.
- DAC coupled with polyvinyl alcohol (PVA) to form hydrogels, with varying DAC/PVA ratios.
- Characterization using imaging, FTIR, XDR, and porosity optimization with salts.
Main Results:
- Successful synthesis of DAC/PVA hydrogels with an intertwined network stabilized by electrostatic interactions and linkages.
- Optimized interconnected porosity (0-50 µm) for tissue engineering requirements.
- DAC 9%/PVA hydrogels demonstrated superior cytocompatibility and in vivo physical stability.
Conclusions:
- DAC/PVA hydrogels are promising biomaterials for soft tissue engineering.
- The DAC 9%/PVA formulation is particularly suitable for soft tissue graft applications.
- This cellulose-based material offers a viable non-proteic scaffold alternative.
