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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Blood Typing01:10

Blood Typing

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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
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Rh Blood Group01:19

Rh Blood Group

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The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
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Blood Types02:20

Blood Types

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Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
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Updated: Oct 15, 2025

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
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Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

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Blood Product (Donor) Noninfectious and Infectious Testing and Modification.

Tania Sarker1, Louis M Katz2, Evan M Bloch3

  • 1Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Emory University School of Medicine, Atlanta, GA 30322, USA.

Clinics in Laboratory Medicine
|October 25, 2021
PubMed
Summary
This summary is machine-generated.

Ensuring blood transfusion safety in the U.S. involves rigorous donor testing and pathogen inactivation. Optimizing the entire blood safety chain minimizes risks from infectious and noninfectious agents.

Keywords:
Blood product testingDonor infectious disease screeningDonor testingResidual riskTransfusion-transmitted infections

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Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
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Area of Science:

  • Transfusion Medicine
  • Public Health
  • Infectious Disease Control

Background:

  • Blood transfusion safety is a critical public health concern.
  • The U.S. blood supply is highly regulated, encompassing the entire safety value chain.
  • Minimizing transfusion-associated risks requires optimization at every stage, from donor selection to post-transfusion surveillance.

Purpose of the Study:

  • To provide an overview of blood donor infectious and noninfectious testing in the United States.
  • To highlight the multifaceted nature of blood transfusion safety.
  • To introduce pathogen inactivation as a key strategy for enhancing blood product safety.

Main Methods:

  • Review of current practices in blood donor selection and testing in the U.S.
  • Discussion of regulatory frameworks governing the U.S. blood supply.
  • Exploration of pathogen inactivation technologies and their role in blood safety.

Main Results:

  • The U.S. employs comprehensive testing for infectious and noninfectious agents in blood donors.
  • Pathogen inactivation offers a significant advancement in reducing transfusion-related risks, including bacterial contamination and viral/parasitic infections.
  • Continuous optimization across the blood safety value chain is essential for risk minimization.

Conclusions:

  • Rigorous donor testing and advanced technologies like pathogen inactivation are crucial for maintaining a safe blood supply in the U.S.
  • A holistic approach to blood safety, addressing all components from donor recruitment to post-transfusion monitoring, is paramount.
  • Ongoing vigilance and implementation of safety measures are necessary to mitigate risks from known and emerging pathogens.