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Related Experiment Video

Updated: Oct 15, 2025

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

Published on: May 11, 2021

A stage-specific cell-manipulation platform for inducing endothelialization on demand.

Qilong Zhao¹, Juan Wang¹, Yunlong Wang¹

¹Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518035, China.

National Science Review

|October 25, 2021

Summary

This summary is machine-generated.

This study introduces a novel bilayer platform that uses near-infrared light to remotely control endothelial cell (EC) functions. This technology promotes faster endothelialization for vascular grafts and stents, improving cardiovascular disease treatment.

Keywords:

biomaterials endothelialization shape-memory polymer tissue engineering topographical conversion

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Last Updated: Oct 15, 2025

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

Published on: May 11, 2021

Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Area of Science:

Biomaterials Science
Regenerative Medicine
Cell Biology

Background:

Endothelialization is crucial for vascular remodeling and the success of cardiovascular implants.
Achieving effective endothelialization on synthetic materials is challenging due to difficulties in mimicking native cell-matrix interactions.
Existing methods struggle to dynamically guide endothelial cell (EC) functions.

Purpose of the Study:

To develop a dynamic, remotely controllable platform for stage-specific endothelial cell manipulation.
To enhance endothelialization processes for vascular grafts and stents.
To provide a versatile tool for biomedical applications requiring stepwise control of cell functions.

Main Methods:

A bilayer platform with near-infrared (NIR)-triggered transformable topographies was designed.
The platform utilizes tunable topographical cues to alter human EC geometries and functions remotely.
NIR triggers induce temporary anisotropic and permanent isotropic topographies sequentially.

Main Results:

The platform successfully altered human EC functions without compromising cell viability.
Temporary anisotropic topographies promoted EC migration.
Permanent isotropic topographies enhanced EC adhesion and spreading, facilitating endothelialization.

Conclusions:

The NIR-triggered bilayer platform enables precise, stage-specific control over EC functions for improved endothelialization.
This technology offers a promising approach for developing next-generation vascular grafts and stents.
The platform has broad potential in tissue regeneration and wound healing applications requiring controlled cell behavior.