Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multi-input and Multi-variable systems01:22

Multi-input and Multi-variable systems

201
Cruise control systems in cars are designed as multi-input systems to maintain a driver's desired speed while compensating for external disturbances such as changes in terrain. The block diagram for a cruise control system typically includes two main inputs: the desired speed set by the driver and any external disturbances, such as the incline of the road. By adjusting the engine throttle, the system maintains the vehicle's speed as close to the desired value as possible.
In the absence...
201
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

121
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
121
Multicompartment Models: Overview01:14

Multicompartment Models: Overview

298
Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
298
Regression Toward the Mean01:52

Regression Toward the Mean

6.6K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.6K
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model01:13

Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model

142
Drugs administered through various routes can lead to nonlinear elimination, resulting in complex pharmacokinetic behaviors crucial to understanding efficacious drug dosing.
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
142
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

799
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
799

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanism of ferroptosis in progressive injury of skeletal muscle caused by high-voltage electrical burns and the intervention effect of uAMC3203.

Burns : journal of the International Society for Burn Injuries·2026
Same author

Spinal cord-like hypertension syndrome with metabolic acidosis and pulmonary edema following lumbar discectomy under general anesthesia: a case report.

BMC anesthesiology·2026
Same author

Real-time soybean pest detection system integrating UAV and Jetson based on improved YOLO.

Neural networks : the official journal of the International Neural Network Society·2026
Same author

Interfacial excess charge dynamics as a quantitative descriptor to understand lithium dendrite growth.

Nature communications·2026
Same author

Direct Identification of Microplastics by Ambient Pyrolysis Electrospray Ionization Mass Spectrometry.

Analytical chemistry·2026
Same author

Mining Association Patterns From Neighborhood Insight.

IEEE transactions on pattern analysis and machine intelligence·2026
Same journal

An Evolutionary Algorithm Assisted by an Ensemble of Pareto-Optimal Surrogate Models.

IEEE transactions on cybernetics·2026
Same journal

A Quantum Self-Attention Neural Network Model on Quantum Circuits.

IEEE transactions on cybernetics·2026
Same journal

Semi-Explicit Solution of Some Discrete-Time Higher-Order-Cost Mean-Field-Type Control.

IEEE transactions on cybernetics·2026
Same journal

A Novel One-Step Small Object Detector for Autonomous Aerial Vehicles.

IEEE transactions on cybernetics·2026
Same journal

Online Data-Driven-Based Optimal Output Tracking Control Without Initial Stabilizing Policy.

IEEE transactions on cybernetics·2026
Same journal

Digital Redesign-Based Interval State Estimation for Continuous Systems With Aperiodic Discrete Measurements.

IEEE transactions on cybernetics·2026
See all related articles

Related Experiment Video

Updated: Oct 15, 2025

Author Spotlight: An Efficient and Robust Software for Automated Fusion of Multiple Preclinical Imaging Modalities
07:13

Author Spotlight: An Efficient and Robust Software for Automated Fusion of Multiple Preclinical Imaging Modalities

Published on: October 27, 2023

1.4K

A Penalty-Based Differential Evolution for Multimodal Optimization.

Zhifang Wei, Weifeng Gao, Genghui Li

    IEEE Transactions on Cybernetics
    |October 26, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Finding multiple global optimal solutions for multimodal optimization problems is challenging. A new penalty-based differential evolution algorithm, PMODE, effectively identifies and refines these solutions using dynamic penalties and elite selection.

    More Related Videos

    Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm
    11:53

    Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm

    Published on: December 9, 2012

    13.1K
    A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
    08:12

    A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments

    Published on: March 1, 2022

    2.6K

    Related Experiment Videos

    Last Updated: Oct 15, 2025

    Author Spotlight: An Efficient and Robust Software for Automated Fusion of Multiple Preclinical Imaging Modalities
    07:13

    Author Spotlight: An Efficient and Robust Software for Automated Fusion of Multiple Preclinical Imaging Modalities

    Published on: October 27, 2023

    1.4K
    Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm
    11:53

    Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm

    Published on: December 9, 2012

    13.1K
    A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
    08:12

    A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments

    Published on: March 1, 2022

    2.6K

    Area of Science:

    • Computational Intelligence
    • Optimization Algorithms
    • Evolutionary Computation

    Background:

    • Locating multiple global optimal solutions (GOSs) for multimodal optimization problems (MMOPs) presents significant computational challenges.
    • Existing algorithms often struggle to efficiently identify diverse sets of optimal solutions in complex search spaces.

    Purpose of the Study:

    • To develop a novel algorithm, Penalty-based Multimodal Optimization Differential Evolution (PMODE), for effectively addressing MMOPs.
    • To enhance the capability of finding multiple GOSs in challenging optimization landscapes.

    Main Methods:

    • PMODE employs a penalty strategy with a dynamic penalty radius to guide the search towards distinct optimal regions.
    • An elite selection mechanism is incorporated to identify promising solutions and focus exploration.
    • The algorithm utilizes the JADE (Jumping Arithmetic Differential Evolution) variant as its core search engine.

    Main Results:

    • PMODE demonstrated superior performance compared to several state-of-the-art multimodal optimization algorithms.
    • Experiments were conducted on 20 MMOPs from the IEEE CEC2013 special session, validating PMODE's effectiveness.
    • The proposed method successfully located multiple GOSs across various benchmark problems.

    Conclusions:

    • PMODE offers a robust and effective approach for solving multimodal optimization problems.
    • The dynamic penalty strategy and elite selection mechanism contribute significantly to finding multiple global optimal solutions.
    • PMODE represents a valuable advancement in the field of evolutionary computation for MMOPs.