Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.8K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shrinky Dinks-Based Bionic Meta-Microneedles for Advancing Wound Healing.

ACS applied materials & interfaces·2026
Same author

A Hydrogel Delivery System Based on Selenium Nanoparticles and bFGF for Promoting the Repair of Skin Wounds.

Biomedicines·2026
Same author

AI-Derived Smart Microneedle Systems for Advanced Wound Management: From Intelligent Sensing to Closed-Loop Therapy.

Macromolecular bioscience·2026
Same author

Ordered micro-nano structures: synergistic integration of microneedles and photonic crystals for advanced biomedical systems.

Journal of materials chemistry. B·2026
Same author

Computational-Aided Mutagenesis of Lipase CRL1 with Promoted Stability and Activity for Biosynthesis of Vitamin E Succinate.

Journal of agricultural and food chemistry·2026
Same author

A Portable and Dual-Button Microneedle Device Enables Intelligent Multimodal Laser Sensing.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Related Experiment Video

Updated: Oct 15, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.6K

Personalized and Programmable Microneedle Dressing for Promoting Wound Healing.

Yuqiu Wang1, Huihui Lu2, Maoze Guo2

  • 1College of Biotechnology and Pharmaceutical Engineering and School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211816, China.

Advanced Healthcare Materials
|October 26, 2021
PubMed
Summary

This study introduces novel microneedle (MN) dressings inspired by mosquito mouthparts for painless transdermal drug delivery in wound healing. These advanced MN dressings offer personalized, programmable, and intelligent drug release, enhancing wound recovery.

Keywords:
microneedlesmosquito mouthpart structurespersonalized designprogrammable needleswound healing

More Related Videos

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.7K
Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.4K

Related Experiment Videos

Last Updated: Oct 15, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.6K
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.7K
Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.4K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Drug Delivery Systems

Background:

  • Microneedle (MN) dressings are crucial for transdermal drug delivery in wound healing.
  • Current MN technologies can cause discomfort due to strong needle penetration.
  • There is a need for advanced MN systems that are painless and adaptable to individual wound characteristics.

Purpose of the Study:

  • To develop a novel microneedle (MN) wound dressing inspired by mosquito mouthparts for intelligent and painless transdermal drug delivery.
  • To engineer MNs with superfine tips, personalized patterns, programmable lengths, and adjustable mechanical strengths.
  • To create a controllable drug release system using temperature-responsive hydrogels and photonic crystals integrated into the MN dressing.

Main Methods:

  • Fabrication of superfine microneedles using stretched silicone rubber molds.
  • Implementation of intelligent image recognition for personalized pattern design tailored to irregular wounds.
  • Integration of N-isopropylacrylamide (NIPAM) hydrogel and inverse opal (IO) photonic crystals (PCs) for controllable drug release.
  • In vivo evaluation of the MN dressing's efficacy on full-thickness skin wounds in a mouse model.

Main Results:

  • Successfully developed microneedle (MN) dressings with superfine tips and personalized designs.
  • Demonstrated programmable needle length and adjustable mechanical strengths for enhanced patient comfort and treatment precision.
  • Achieved controllable drug release kinetics through the integration of NIPAM hydrogel and IO photonic crystals.
  • Validated the MN dressing's effectiveness in promoting wound healing in a preclinical mouse model.

Conclusions:

  • The novel microneedle (MN) wound dressing offers a significant advancement in painless and intelligent transdermal drug delivery.
  • Personalized design, programmable features, and controlled release capabilities highlight the potential of these MNs for improved wound management.
  • These findings underscore the considerable value of advanced MN wound dressings in the field of wound care and regenerative medicine.